Palmitoylethanolamide (PEA) is a naturally occurring fatty acid that has been studied to show neuroprotective, anti-inflammatory, cardioprotective and analgesic pain relief properties.




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PEA is a naturally occurring fatty acid found mainly in egg yolks and mothers milk, but is also naturally produced by the body in response to pain.

As a supplement, it has been studied to show neuro-protective, anti-inflammatory, and analgesic (pain-relieving) properties.

PEA Belongs to the endocannabinoid family therefore acts on similar receptors to cannabis oil; it is a fully legal and similarly efficacious alternative to CBD oil.

In several studies focused on management of chronic pain, PEA was shown to have potent anti-inflammatory and analgesic effects, therefore and may help with the treatment of chronic pain.

PEA is being used in functional medicine for many disease states including fibromyalgia, osteoarthritis, MS, carpal tunnel syndrome and autism.

It also shows potent neuroprotective and cardioprotective effects due to it being a fatty acid, fats have an affinity for the brain and heart (fat using organs) therefore may help with CNS and Neurological inflammatory issues, as well are cardiac issues such as myocarditis and pericarditis. 

It also may help with histamine issue and MCAS issues, as it is a strong anti-histamine, mast cell stabilising ingredient. 


Each bottle contains 60 capsules; 30 serves.


Legal Disclaimer:
*All product information available on the website is for educational purposes only,

Bodily introduction of any kind into humans is done at the person’s own
risk, and LVLUP Health makes no health claims, and assumes no responsibility for health outcomes, good or bad, that may result from ingestion or use of this product. Use should be supervised by a qualified healthcare professional. 



Conditions with evidence of Benefit with PEA

1.         Arthritis – osteoarthritis & rheumatoid athritis

2.         Fibromyalgia

3.         Peripheral neuropathies – diabetic neuropathy & chemotherapy-induced peripheral neuropathy

4.         Carpal tunnel syndrome

5.         Opioid Tolerance and Hyperalgesia

6.         Low back pain – herniated disc disease, failed back surgery syndrome, other

7.         Sciatic pain

8.         Dental pain

9.         Neuropathic pain – related to stroke & multiple sclerosis

10.     Inflammatory Bowel Disease

11.     Chronic pelvic pain

12.     Shingles pain (postherpetic neuralgia)

13.     Vaginal pain (vulvadynia)

14.     Post-operative dental surgery pain
15.     Traumatic Brain Injury/Chronic Traumatic Encephalopathy



Taken once per day with or without food.
500mg per capsule/serve
0.5-1.5g per day recommended dose (1-3 capsules)


Brcic, L., Brcic, I., Staresinic, M., Novinscak, T., Sikiric, P., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society, 60 Suppl 7, 191–196.

Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of Orthopaedic Research, 28(9), 1155–1161.

Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. S. (2014). Pentadecapeptide bpc 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules, 19(11), 19066–19077.

Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Su Pang, J. H. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780.

Gjurasin, M., Miklic, P., Zupancic, B., Perovic, D., Zarkovic, K., Brcic, L., … Sikiric, P. (2010). Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury. Regulatory Peptides, 160(1–3), 33–41.

Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159.

Perovic, D., Kolenc, D., Bilic, V., Somun, N., Drmic, D., Elabjer, E., … Sikiric, P. (2019). Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. Journal of Orthopaedic Surgery and Research, 14(1), 1–12.

Pevec, D., Novinscak, T., Brcic, L., Sipos, K., Jukic, I., Staresinic, M., … Sikiric, P. (2010). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical Science Monitor, 16(3), 81–88.

Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … Kolega, Z. (1997). BPC 157’s effect on healing. Journal of Physiology Paris, 91(3–5), 173–178.

Sever, A. Z., Sever, M., Vidovic, T., Lojo, N., Kolenc, D., Vuletic, L. B., … Sikiric, P. (2019). Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation. European Journal of Pharmacology, 847(January), 130–142.

Sikiric, P. (1999). The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology, 7(1), 1–14.

Sikiricc, P., Petek, M., Rucman, R., Seiwerth, S., Grabarevic, Z., Rotkvic, I., … Karakas, I. (1993). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. Journal of Physiology – Paris, 87(5), 313–327.

Sikiric, P., Seiwerth, S., Kolenc, D., Grgic Klinicka bolnica, T., Duh, S., Rucman, R., … Vlainic, J. (2018). Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications Article in DNA research: an international journal for rapid publication of reports on genes and genomes · May 2016 CITATIONS 12 READS 793 Genetic and epigenetic biomarkers of innate immunity in COPD and lung cancer View project BPC 157

Staresinic, M., Sebecic, B., Patrlj, L., Jadrijevic, S., Suknaic, S., Perovic, D., … Sikiric, P. (2003). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. Journal of Orthopaedic Research, 21(6), 976–983. [/expand]

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